18228-17-6 , Naphthol AS-E phosphate; KG-501

18228-17-6 , Naphthol AS-E phosphate;
KG-501; N-(4-Chlorophenyl)-3-(phosphonooxy)-2-naphthalenecarboxamide,
Cas:18228-17-6
C17H13ClNO5P / 377.72
MFCD00042718

Naphthol AS-E phosphate

KG-501; N-(4-Chlorophenyl)-3-(phosphonooxy)-2-naphthalenecarboxamide

Naphthol AS-E phosphate is an inhibitor of the protein-protein interaction between CREB and the KIX domain of CREB-binding protein (CBP; Ki = 50 µM). It also inhibits the binding of the transcription factor Myb to the KIX domains of p300 and CBP (IC50s = 30 and 43 µM, respectively). Naphthol AS-E phosphate inhibits CREB-dependent transcription in HEK293T cells (Ki = 10 µM). It also decreases the expression of Myb target genes and induces differentiation in HL-60, U937, and NB4 myeloid leukemia cells when used at a concentration of 5 µM. Naphthol AS-E phosphate inhibits proliferation of NCI-H1734 lung adenocarcinoma cells (IC50 = 6.89 µM).

KG-501 is a cAMP response element-binding protein (CREB) inhibitor.

CAS Number	18228-17-6
Product Name	N-(4-Chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide
IUPAC Name	[3-[(4-chlorophenyl)carbamoyl]naphthalen-2-yl] dihydrogen phosphate
Molecular Formula	C17H13ClNO5P
Molecular Weight	377.7 g/mol
InChI	InChI=1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)
InChI Key	RQAQWBFHPMSXKR-UHFFFAOYSA-N
SMILES	C1=CC=C2C=C(C(=CC2=C1)C(=O)NC3=CC=C(C=C3)Cl)OP(=O)(O)O
Solubility	Soluble in DMSO
Synonyms	KG 501, KG-501, KG501 cpd, naphthol AS-E phosphate
Canonical SMILES	C1=CC=C2C=C(C(=CC2=C1)C(=O)NC3=CC=C(C=C3)Cl)OP(=O)(O)O