3083-77-0 , Arabinofuranosyluracil, CAS:3083-77-0

3083-77-0, Arabinofuranosyluracil,
CAS:3083-77-0
C9H12N2O6 / 244.201
MFCD00065998

阿糖尿苷, Arabinofuranosyluracil

Ara-C is a cytotoxic anti-cancer drug that acts as an equilibrative nucleoside and inhibits DNA synthesis by blocking the enzyme arabinoside kinase. Ara-C is used in the treatment of human malignancies, including lymphocytic leukemia and other leukemias. Ara-C has been shown to be effective in low doses against squamous cell carcinoma. This drug also interacts with other drugs, so it should not be taken with drugs such as ara-c or chloramphenicol.

CAS Number	3083-77-0
Product Name	Spongouridine
IUPAC Name	1-[(3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Molecular Formula	C9H12N2O6
Molecular Weight	244.2 g/mol
InChI	InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7+,8?/m1/s1
InChI Key	DRTQHJPVMGBUCF-CCXZUQQUSA-N
SMILES	C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
Solubility	Soluble in DMSO
Synonyms	1 beta D Arabinofuranosyl Uracil, 1-beta-D-Arabinofuranosyl Uracil, Ara U, Ara-U, Arabinofuranoside, Uracil, Arabinofuranosyluracil, Arabinoside, Uracil, Arabinosyluracil, Arauridine, NSC 68928, Sponguridine, Uracil Arabinofuranoside, Uracil Arabinoside, Uracil, 1-beta-D-Arabinofuranosyl
Canonical SMILES	C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
Isomeric SMILES	C1=CN(C(=O)NC1=O)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O