66091-34-7 , Colchicine fluorescein

Cas:66091-34-7 ,
Colchicine fluorescein
C41H34N2O10S / 746.78
MFCD00467657

Colchicine fluorescein

Fluoregenic form of colchicine for staining and inhibit assembly of tublin.

Colchicine fluorescein is a fluorescent colchicine analog that has been shown to be effective in the detection of human serum. This drug is not active and does not bind to DNA or RNA. It is used for the detection of cancer cells and measurement of cardiac function. Colchicine fluorescein binds to the cell membrane by interacting with p-glycoprotein and inhibits the efflux pump activity, causing dilations in the cells. Colchicine fluorescein can also be used as a substrate for photodecomposition and microscopy.

CAS Number	66091-34-7
Product Name	Colchicine fluorescein
IUPAC Name	1-(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)-3-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)thiourea
Molecular Formula	C41H34N2O10S
Molecular Weight	746.8 g/mol
InChI	InChI=1S/C41H34N2O10S/c1-48-32-14-9-24-25(19-31(32)46)30(13-5-20-15-35(49-2)37(50-3)38(51-4)36(20)24)43-40(54)42-21-6-10-27-26(16-21)39(47)53-41(27)28-11-7-22(44)17-33(28)52-34-18-23(45)8-12-29(34)41/h6-12,14-19,30,44-45H,5,13H2,1-4H3,(H2,42,43,54)
InChI Key	DQCILGJBPWFBHI-UHFFFAOYSA-N
SMILES	COC1=CC=C2C(=CC1=O)C(CCC3=CC(=C(C(=C32)OC)OC)OC)NC(=S)NC4=CC5=C(C=C4)C6(C7=C(C=C(C=C7)O)OC8=C6C=CC(=C8)O)OC5=O
Synonyms	fluorescein colchicine
Canonical SMILES	COC1=CC=C2C(=CC1=O)C(CCC3=CC(=C(C(=C32)OC)OC)OC)NC(=S)NC4=CC5=C(C=C4)C6(C7=C(C=C(C=C7)O)OC8=C6C=CC(=C8)O)OC5=O