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69-65-8, D-Mannitol, CAS:69-65-8

69-65-8, D-Mannitol,CAS:69-65-8
C6H14O6 / 182.17
MFCD00064287

D-甘露醇 , D-Mannitol

Title: Mannitol

CAS Registry Number: 69-65-8

Additional Names: D-Mannitol; mannite; manna sugar; cordycepic acid

Trademarks: Manicol; Mannidex; Osmitrol (Baxter); Osmosal; Resectisol (McGaw)

Molecular Formula: C6H14O6

Molecular Weight: 182.17

Percent Composition: C 39.56%, H 7.75%, O 52.70%

Literature References: Widespread in plants and plant exudates; obtained from manna and seaweeds: The Carbohydrates, W. Pigman, Ed. (Academic Press, New York, 1957) pp 249-250. Forms a stable, equimolar compound with H2O2: S. Tanatar, J. Russ. Phys. Chem. Soc. 40, 376, C.A. 3, 883 (1909). Prepd by electrolytic reduction of glucose: Creighton, Can. Chem. Process Ind. 26, 690 (1942), C.A. 37, 10885 (1943); Wolfrom et al., J. Am. Chem. Soc. 68, 578 (1946). Prepn from seaweed: Sorensen, Kristensen, US 2516350 (1950); by hydrogenation of invert sugar, monosaccharides, and sucrose: Kasehagen, and Kasehagen, Luskin, US 2642462, US 2749371, and US 2759024 (1953, 1956, and 1956, all to Atlas Powder). Review of prepn: Pigman, loc. cit. Novel synthesis: M. Makkee et al., Chem. Commun. 1980, 930.

Properties: Orthorhombic needles from alc, mp 166-168°. Sweetish taste. d20 1.52. bp3.5 290-295°. Is inactive or very slightly levorotatory in distilled water. Forms sodium mannitoborate on addition of borax giving a greater rotation: [a]D20 +23° ® +24° after 1 hr in a soln of 10 g mannitol +12.8 g borax + sufficient H2O to make 100 ml. One gram dissolves in ~5.5 ml water, 83 ml alcohol; more sol in hot water. Insol in ether. Sol in pyridine, aniline, aq solns of alkalies. One gram dissolves in 18 ml glycerol (d 1.24). Soly tables: Creighton, Klauder, J. Franklin Inst. 195, 687 (1923). pKa (18°): 13.50.

Melting point: mp 166-168°

Boiling point: bp3.5 290-295°

pKa: pKa (18°): 13.50

Optical Rotation: [a]D20 +23° ® +24° after 1 hr in a soln of 10 g mannitol +12.8 g borax + sufficient H2O to make 100 ml

Density: d20 1.52; d 1.24

Use: Used with boric acid in the manuf of dry electrolytic condensers for radio applications; in making artificial resins and plasticizers; in pharmacy as excipient and diluent for solids and liqs; in analytical chemistry for boron determinations; in the manuf of mannitol hexanitrate. Used in the food industry as anticaking and free-flow agent, flavoring agent, lubricant and release agent, stabilizer and thickener and nutritive sweetener.

Therap-Cat: Diuretic. Diagnostic aid (renal function).

Keywords: Diagnostic Aid; Diuretic.

CAS Number69-65-8
Product NameMannitol
IUPAC Name(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
Molecular FormulaC6H14O6
Molecular Weight182.17 g/mol
InChIInChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
InChI KeyFBPFZTCFMRRESA-KVTDHHQDSA-N
SMILESC(C(C(C(C(CO)O)O)O)O)O
Solubilitygreater than or equal to 100 mg/mL at 68° F (NTP, 1992)
216000 mg/L (at 25 °C)
1 g in about 5.5 ml water; more sol in hot water; insol in ether; sol in pyridine, aniline; sol in aq soln of alkalies; 1 g dissolves in 18 ml glycerol (density 1.24); 1 g dissolves in about 83 ml alc
In water, 2.16X10+5 mg/l @ 25 °C
216 mg/mL at 25 °C
Synonyms(L)-Mannitol, Mannitol, Osmitrol, Osmofundin
Canonical SMILESC(C(C(C(C(CO)O)O)O)O)O
Isomeric SMILESC([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O

Name: D-Mannitol   CAS69-65-8              M.F.: C6H14O6

M.W.182.17         Batch No20120403 Quantity:262g

Items

Standards

Results

Appearance

White crystalline power

Positive

Solubility

Readily soluble in water and

insoluble in ether

Positive

NMR and MS

Should comply

Complies

Identification

IR and TLC

Positive

M.P.

160 ~170

162 ~165

Loss Weight On Dryness

Max. 1%

Complies

Heavy Metal

Max. 20ppm

Complies

TLC (15%H2SO4-C2H5OH)

One spot

Complies

Assay (HPLC)

Min. 98%

99.6%


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