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  • 16838-89-4 , 2,3,5-三苄基-b-D-呋喃核糖, CAS:16838-89-4
16838-89-4 , 2,3,5-三苄基-b-D-呋喃核糖, CAS:16838-89-4

16838-89-4 , 2,3,5-三苄基-b-D-呋喃核糖, CAS:16838-89-4

16838-89-4 , 2,3,5-Tri-O-benzyl-b-D-ribofuranose,
2,3,5-三苄基-b-D-呋喃核糖,
CAS:16838-89-4
Remdesivir
C26H28O5 / 420.5
MFCD18643128

2,3,5-Tri-O-benzyl-b-D-ribofuranose

2,3,5-三苄基-b-D-呋喃核糖,

2,3,5-Tri-O-benzyl-D-ribofuranose is a carbohydrate that can be synthesized through an efficient method. It is a glycoside with an oxotitanium (oxo) group. The synthesis of this compound requires magnesium as the activating agent and o-glycosylation. The glycoconjugates of this compound are found in organisms such as fungi, yeast, and bacteria. In addition to its carbohydrate function, 2,3,5-Tri-O-benzyl-D-ribofuranose has been shown to have antimicrobial properties. This sugar has also been shown to have antiviral properties due to its ability to inhibit the enzyme ribonucleotide reductase (RNR).

2,3,5-Tri-O-benzyl-D-ribofuranose, also known as benzylated ribose or TBR, is a derivative of ribose, a five-carbon sugar often found in RNA. TBR has been synthesized and extensively studied due to its potential applications in various fields, such as organic chemistry, biochemistry, and materials science.

Synthesis and Characterization:

TBR can be synthesized from ribose using a benzyl protection strategy. The synthesis involves protecting all three hydroxyl groups of ribose with benzyl groups using benzyl chloride and a base catalyst. The product is then purified by column chromatography and characterized by various spectroscopic techniques, such as ^1H and ^13C NMR spectroscopy and mass spectrometry.

Analytical Methods:

Various analytical methods have been developed to detect and quantify TBR. High-performance liquid chromatography (HPLC) coupled with UV and/or mass spectrometry is frequently used to determine TBR concentration and purity in synthetic and biological samples.

Biological Properties:

TBR has been investigated for its potential biological activity as a glycosidase inhibitor, which may have implications in treating certain diseases such as cancer and diabetes. It has also been shown to be a potent inhibitor of RNA viruses and could have antiviral applications.

Toxicity and Safety in Scientific Experiments:

Studies on the toxicity of TBR are limited. However, it has been reported that benzylated sugars may be toxic to certain cell lines at high concentrations. Therefore, caution should be taken when handling TBR and appropriate safety measures should be implemented.

Applications in Scientific Experiments:

TBR has been used as a versatile building block for the synthesis of various glycosylated compounds, such as oligonucleotides, nucleotide analogs, and glycosylated drugs. Its potential applications in the synthesis of glycoconjugates and other bioactive molecules have been extensively investigated. TBR has also been studied for its potential use in developing new biosensors.

Current State of Research:

The synthesis and applications of TBR continue to be an area of active research. Recent studies have focused on developing new and efficient synthetic strategies for TBR and its derivatives, as well as investigating their biological activity and potential applications in various fields.

Potential Implications in Various Fields of Research and Industry:

TBR and its derivatives have potential applications in various fields such as drug development, materials science, and carbohydrate chemistry. Its use in the synthesis of bioactive molecules and materials may have implications in the development of new therapeutic agents and advanced materials.

Limitations and Future Directions:

Despite its potential applications, the use of TBR is currently limited by its high cost and complicated synthetic procedures. Future research will focus on developing more cost-effective and efficient synthetic strategies for TBR and its derivatives. Additionally, further studies on the biological activity and toxicity of TBR are needed to fully understand its potential applications in various fields.

Future Directions:

1. Development of more efficient and cost-effective synthetic strategies for TBR and its derivatives

2. Investigation of the biological activity and mechanism of action of TBR and its derivatives

3. Synthesis and characterization of TBR-based bioactive molecules for drug development

4. Study of the physical and chemical properties of TBR and its derivatives in various matrices including biosensors and advanced materials

5. Exploration of TBR-based glycoconjugates for developing novel therapeutics

6. Design and synthesis of novel TBR derivatives with improved properties for various applications

7. Establishment of more efficient analytical methods for detecting and quantifying TBR in synthetic and biological samples.

CAS Number16838-89-4
Product Name2,3,5-Tri-O-benzyl-D-ribofuranose
IUPAC Name(3R,4R,5R)-3,4-bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolan-2-ol
Molecular FormulaC26H28O5
Molecular Weight420.5 g/mol
InChIInChI=1S/C26H28O5/c27-26-25(30-18-22-14-8-3-9-15-22)24(29-17-21-12-6-2-7-13-21)23(31-26)19-28-16-20-10-4-1-5-11-20/h1-15,23-27H,16-19H2/t23-,24-,25-,26?/m1/s1
InChI KeyNAQUAXSCBJPECG-NITSXXPLSA-N
SMILESC1=CC=C(C=C1)COCC2C(C(C(O2)O)OCC3=CC=CC=C3)OCC4=CC=CC=C4
Canonical SMILESC1=CC=C(C=C1)COCC2C(C(C(O2)O)OCC3=CC=CC=C3)OCC4=CC=CC=C4
Isomeric SMILESC1=CC=C(C=C1)COC[C@@H]2[C@H]([C@H](C(O2)O)OCC3=CC=CC=C3)OCC4=CC=CC=C4


CAS No:89361-52-4,16838-89-4 MDL No:MFCD18643128 Chemical Formula:C26H28O5 Molecular Weight:420.5
References:1. Parsch J, Engels JW,, HELVETICA CHIMICA ACTA, 2000, 83, p1791Remdesivir                                                起始原料,大量现货供应

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