N-Allyloxycarbonyl-b-lactosamine

The linker N-Allyloxycarbonyl-b-lactosamine (NALB) is a bifunctional molecule that can be used to form triplexes with DNA. The NALB has been shown to inhibit the growth of gram-negative bacteria such as Escherichia coli and Haemophilus influenzae by binding to the bacterial cell wall and disrupting its permeability. The linker is synthesized by solid phase synthesis. This process involves the stepwise addition of building blocks in a sequence that is predetermined. The residues are usually protected with protecting groups, which are then removed at the end of the synthesis process.