37067-30-4, 4-甲基伞形酮-b-D-乙酰氨基葡萄糖苷,4-MU-GlcNAc, CAS: 37067-30-4

4-MU-GlcNAc
GlcNAc-b-4MU
4-Methylumbelliferyl N-acetyl-β-D-glucosaminide, CAS: 37067-30-4
C18H21NO8.2H2O / 415.4
MFCD00065481

4-Methylumbelliferyl 2-acetamido-2-deoxy-b-D-glucopyranoside

4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside is a fluorogenic substrate for β-hexosaminidases. Upon enzymatic cleavage by β-hexosaminidases, 4-methylumbelliferone (4-ΜU) is released and its fluorescence can be used to quantify β-hexosaminidase activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside has been used to quantify β-hexosaminidase activity in serum or leukocytes from patients with GM2 gangliosidoses such as Tay-Sachs disease, which is characterized by defects in the α subunit of β-hexosaminidase.

CAS Number	37067-30-4
Product Name	4-Methylumbelliferyl-N-acetyl-beta-D-glucosaminide
IUPAC Name	N-[(3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]acetamide
Molecular Formula	C18H21NO8
Molecular Weight	379.4 g/mol
InChI	InChI=1S/C18H21NO8/c1-8-5-14(22)26-12-6-10(3-4-11(8)12)25-18-15(19-9(2)21)17(24)16(23)13(7-20)27-18/h3-6,13,15-18,20,23-24H,7H2,1-2H3,(H,19,21)/t13-,15-,16-,17-,18?/m1/s1
InChI Key	QCTHLCFVVACBSA-JVNHZCFISA-N
SMILES	CC1=CC(=O)OC2=C1C=CC(=C2)OC3C(C(C(C(O3)CO)O)O)NC(=O)C
Synonyms	4-methylumbelliferyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside, 4-methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside, 4-methylumbelliferyl-N-acetyl-beta-D-glucosaminide, 4-methylumbelliferyl-N-acetyl-beta-glucosamine, 4-methylumbelliferyl-N-acetylglucosaminide, 4-MU-Glc-NAc, 4-MUAG, MUABG
Canonical SMILES	CC1=CC(=O)OC2=C1C=CC(=C2)OC3C(C(C(C(O3)CO)O)O)NC(=O)C
Isomeric SMILES	CC1=CC(=O)OC2=C1C=CC(=C2)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)NC(=O)C

CAS No: 37067-30-4 Synonyms: 4-Methylumbelliferyl N-acetyl-b-D-glucosaminide4-MU-GlcNAcGlcNAc-b-4MU MDL No: MFCD00065481 Chemical Formula: C18H21NO8.2H2O Molecular Weight: 415.4

White crystal powder.

In Stock.现货

COA:

Product name: 4-Methylumbelliferyl N-acetyl-β-D-glucosaminide dihydrate

CAS: 37067-30-4 M.F.: C₁₈H₂₁NO₈.2H₂O M.W._:415.4

*Items*	*Standards*	*Results*
Appearance	White crystal powder	Complies
Solubility	Soluble in DMF, insoluble ether	Complies
Identification	IR and HPLC	Complies
NMR and MS	Should comply	Complies
Melting point	208℃ ~ 215 °C	208℃ ~210℃
Heavy metal	Max. 20ppm	Complies
Residue on ignition	Max. 0.5%	0.1%
Water Content （K.F.）	Max. 2%	0.9%
4-Methylumbelliferone	Max. 0.1%	Complies
TLC	Should be one spot	One spot
Assay by HPLC	Min. 98%	99.2%