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  • 4305-74-2 , L-甘油基-D-甘露庚糖, CAS:4305-74-2
4305-74-2 , L-甘油基-D-甘露庚糖, CAS:4305-74-2

4305-74-2 , L-甘油基-D-甘露庚糖, CAS:4305-74-2

4305-74-2 , L-甘油基-D-甘露庚糖,
L-Glycero-D-mannoheptose,
CAS:4305-74-2
C7H14O7 / 210.18
MFCD00269999

L-甘油基-D-甘露庚糖, L-Glycero-D-manno-heptose

L-Glycero-D-manno-heptose is a polymyxin B antimicrobial agent that has been shown to have significant activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae. This compound also has an inhibitory effect on the growth of Gram-negative species such as Salmonella enterica. L-Glycero-D-manno-heptose inhibits the synthesis of bacterial cell wall peptidoglycan by binding to the terminal residues of oligosaccharides, which are linked to D-alanine in the peptidoglycan chain. The terminal residues of oligosaccharides are transferred from the lipid carrier to L-glycero-D manno heptose, forming a stable acylated glycoside. This reaction mechanism is similar to that of polymyxin B, but with a difference in reactivity due to steric hindrance.

CAS Number4305-74-2
Product Nameglycero-manno-Heptose
IUPAC Name(2S,3S,4R,5R,6S)-2,3,4,5,6,7-hexahydroxyheptanal
Molecular FormulaC₇H₁₄O₇
Molecular Weight210.18 g/mol
InChIInChI=1S/C7H14O7/c8-1-3(10)5(12)7(14)6(13)4(11)2-9/h1,3-7,9-14H,2H2/t3-,4+,5-,6-,7+/m1/s1
InChI KeyYPZMPEPLWKRVLD-BIVRFLNRSA-N
SMILESC(C(C(C(C(C(C=O)O)O)O)O)O)O
Solubility0.48 M
SynonymsD-glycero-D-manno-heptose, glycero-manno-heptose, glycero-manno-heptose, (D-glycero-D-manno)-isomer, glycero-manno-heptose, (D-glycero-L-manno)-isomer, L-glycero-D-manno-heptose
Canonical SMILESC(C(C(C(C(C(C=O)O)O)O)O)O)O
Isomeric SMILESC([C@@H]([C@H]([C@H]([C@@H]([C@@H](C=O)O)O)O)O)O)O


CAS No: 4305-74-2 MDL No: MFCD00269999 Chemical Formula: C7H14O7 Molecular Weight: 210.18
References: 1. Boons GJ, van der Klein PAM, van der Marel GA, van Boom JH, Recl. Trav. Chim. 1988, 108, p5072. Teuber M, et al., Biochemistry 1968, 7, 9, p33033. Brade H, Galanos C, Infec. Immun. 1983, 42, p2504. Balla E, Zamyatina A, Andreas Hofingera A, Kosma P, Carbohyd. Res. 2007, 342, 17, p2537-2545


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