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  • 62480-44-8 , L-Leucine 7-amido-4-methylcoumarin hydrochloride
62480-44-8 , L-Leucine 7-amido-4-methylcoumarin hydrochloride

62480-44-8 , L-Leucine 7-amido-4-methylcoumarin hydrochloride

Cas:62480-44-8 ,
L-Leucine 7-amido-4-methylcoumarin hydrochloride;
L-Leucine (4-methyl-7-coumarinylamide) hydrochloride; H-Leu-AMC · HCl
C16H21ClN2O3 / 324.81
MFCD00043262

L-Leucine 7-amido-4-methylcoumarin hydrochloride;

L-Leucine (4-methyl-7-coumarinylamide) hydrochloride; H-Leu-AMC · HCl

Fluorogenic substrate for leucine aminopeptidase.

L-Leu-AMC is a fluorogenic substrate for leucine aminopeptidase. Upon enzymatic cleavage by leucine aminopeptidase, AMC is released and its fluorescence can be used to quantify leucine aminopeptidase activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

L-Leucine 7-Amido-4-methylcoumarin Hydrochloride is a fluorogenic substrate for LAP3 (leucine aminopeptidase). Upon enzyme activity, a bright blue fluorescent dye, 7-amino-4-methylcoumarin, is released.

L-Leucine 7-amido-4-methylcoumarin hydrochloride salt is a protease inhibitor that has been shown to inhibit the activity of serine proteases. It has been shown to have potential as a drug target, and has also been shown to be effective in wastewater treatment. The biochemical properties of L-Leucine 7-amido-4-methylcoumarin hydrochloride salt have been investigated using sephadex G-100 chromatography and phosphatase activity assays. This molecule has also been shown to affect physiological function and enzyme activities in rats. L-Leucine 7-amido-4-methylcoumarin hydrochloride salt is metabolized by microbial enzymes, such as proteases, which may produce ATP as an energy source.

CAS Number62480-44-8
Product NameL-Leucine-7-amido-4-methylcoumarin hydrochloride
IUPAC Name(2S)-2-amino-4-methyl-N-(4-methyl-2-oxochromen-7-yl)pentanamide;hydrochloride
Molecular FormulaC16H20N2O3*HCl
Molecular Weight324,8 g/mole
InChIInChI=1S/C16H20N2O3.ClH/c1-9(2)6-13(17)16(20)18-11-4-5-12-10(3)7-15(19)21-14(12)8-11;/h4-5,7-9,13H,6,17H2,1-3H3,(H,18,20);1H/t13-;/m0./s1
SMILESCC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CC(C)C)N.Cl


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