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  • 6559-91-7, 4'-去甲表鬼臼毒素, 4'-Demethylepipodophyllotoxin, CAS: 6559-91-7
  • 6559-91-7, 4'-去甲表鬼臼毒素, 4'-Demethylepipodophyllotoxin, CAS: 6559-91-7
6559-91-7, 4'-去甲表鬼臼毒素, 4'-Demethylepipodophyllotoxin, CAS: 6559-91-76559-91-7, 4'-去甲表鬼臼毒素, 4'-Demethylepipodophyllotoxin, CAS: 6559-91-7

6559-91-7, 4'-去甲表鬼臼毒素, 4'-Demethylepipodophyllotoxin, CAS: 6559-91-7

6559-91-7, 4'-去甲表鬼臼毒素,
4'-Demethylepipodophyllotoxin,
CAS: 6559-91-7
C21H20O8 / 400.379
MFCD00189421

4'-去甲表鬼臼毒素, 

4'-Demethylepipodophyllotoxin

Demethylepipodophyllotoxin is a naturally occurring compound that has been shown to inhibit the mitochondrial membrane potential, which may lead to cell death. Demethylepipodophyllotoxin also inhibits the production of low-density lipoprotein cholesterol (LDL-C). This drug has been shown to be effective in reducing the size of solid tumours and resistant mutants in a mouse model. Demethylepipodophyllotoxin binds to the DNA template, preventing DNA synthesis and promoting cell death by inhibiting enzymes activities. Demethylepipodophyllotoxin has been shown to have antimicrobial properties against bacteria, fungi and protozoa as well as antitumour effects on cancer cells.

CAS Number6559-91-7
Product Name4'-Demethylepipodophyllotoxin
IUPAC Name(5R-(5alpha,5abeta,8aalpha,9beta))-5,8,8a,9-Tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one
Molecular FormulaC21H20O8
Molecular Weight400.379 g/mol
InChIInChI=1S/C21H20O8/c1-25-15-3-9(4-16(26-2)20(15)23)17-10-5-13-14(29-8-28-13)6-11(10)19(22)12-7-27-21(24)18(12)17/h3-6,12,17-19,22-23H,7-8H2,1-2H3/t12-,17+,18-,19+/m0/s1
InChI KeyYVCVYCSAAZQOJI-JHQYFNNDSA-N
SMILESO=C1OC[C@]2([H])[C@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(O)C(OC)=C5)[C@]21[H]
SolubilitySoluble in DMSO
Synonyms4'-demethyl epipodophyllotoxin, 4'-demethylepipodophyllotoxin
Canonical SMILESCOC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
Isomeric SMILESCOC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O

COA:

Product name: 4'-Demethylepipodophyllotoxin                      CAS: 6559-91-7

M.F.: C21H20O8     M.W.: 400.379           Quantity:3.8kg

Items

Standards

Results

Appearance

White or off-white crystal powder

Complies

Solubility

Soluble in DMF, insoluble in water

Complies

Identification

IR and HPLC

Complies

NMR and MS

Should comply

Should comply

Total impurity

Max. 2%

Complies

Heavy metal

Max. 50ppm

Complies

Residue on ignition

Max. 0.5%

0.01%

TLC

One spot

One spot

Assay by HPLC

Min. 98%

98.2%

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