C-HEGA-10, Cyclohexylbutanoyl-N-hydroxyethylglucamide

1-[(4-环己基-1-氧代丁基)(2-羟基乙基)氨基]-1-脱氧-D-山梨糖醇,

Cyclohexylbutanoyl-N-hydroxyethylglucamide (CHBE) is a nitrite reductase inhibitor that has been shown to be effective in plant cell cultures and in proton uptake assays. It inhibits the biosynthesis of cyclic guanosine monophosphate (cGMP), which is an important regulator of smooth muscle relaxation. CHBE has been shown to inhibit nitrite reductase activity, as well as cavity formation and protein synthesis in the bacteria typhimurium. This drug also binds to the active site of nitrite reductase, inhibiting its function by stabilising a reduced form of the enzyme.