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  • 14215-68-0 , 2-乙酰氨基-D-半乳糖, N-乙酰-D-半乳糖胺,GalNAc, CAS:14215-68-0
  • 14215-68-0 , 2-乙酰氨基-D-半乳糖, N-乙酰-D-半乳糖胺,GalNAc, CAS:14215-68-0
14215-68-0 , 2-乙酰氨基-D-半乳糖, N-乙酰-D-半乳糖胺,GalNAc, CAS:14215-68-014215-68-0 , 2-乙酰氨基-D-半乳糖, N-乙酰-D-半乳糖胺,GalNAc, CAS:14215-68-0

14215-68-0 , 2-乙酰氨基-D-半乳糖, N-乙酰-D-半乳糖胺,GalNAc, CAS:14215-68-0

2-乙酰氨基-D-半乳糖,
N-乙酰-D-半乳糖胺,
CAS:14215-68-0
C8H15NO6 / 221.21
MFCD00065372

2-乙酰氨基-D-半乳糖, N-乙酰-D-半乳糖胺

N-Acetyl-D-galactosamine

N-Acetyl-D-Galactosamine (GalNAc) is a monosaccharide that is commonly found in glycoconjugates, which are molecules containing carbohydrates that are linked to other biomolecules, such as proteins or lipids. GalNAc has been a topic of interest in scientific research due to its relevance in many biological processes, including cell adhesion, signal transduction, and host-pathogen interactions. In this paper, we will explore the definition, physical and chemical properties, synthesis and characterization, analytical methods, biological properties, toxicity and safety in scientific experiments, applications in scientific experiments, current state of research, potential implications in various fields of research and industry, limitations, and future directions of GalNAc.

DEFINITION AND BACKGROUND:

GalNAc is a carbohydrate that belongs to the N-acetylhexosamine family, which also includes N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalN). GalNAc is composed of a hexose sugar (galactose) and an amino group that is acetylated. It is commonly found in various glycoconjugates, including glycoproteins, proteoglycans, and glycolipids. GalNAc plays an essential role in many biological processes, including cell adhesion, migration, signaling, and host-pathogen interactions. GalNAc-binding proteins also have therapeutic potential in the treatment of various diseases, including cancer.

PHYSICAL AND CHEMICAL PROPERTIES:

GalNAc is a white crystalline powder that is soluble in water and ethanol. It has a molecular weight of 221.21 g/mol and a melting point of 208-210°C. GalNAc's chemical structure consists of a hexose sugar (galactose) and an amino group that is acetylated. GalNAc is stable under ordinary conditions, but it is susceptible to hydrolysis in acidic or alkaline environments.

SYNTHESIS AND CHARACTERIZATION:

GalNAc can be synthesized using various methods, such as enzymatic and chemical synthesis. Enzymatic synthesis involves the use of glycosyltransferases, which catalyze the transfer of sugar moieties to acceptor molecules. Chemical synthesis involves the use of protecting groups, which are added to functional groups to prevent unwanted reactions.

ANALYTICAL METHODS:

GalNAc can be analyzed using various techniques, including high-performance liquid chromatography (HPLC), mass spectrometry (MS), and nuclear magnetic resonance (NMR). HPLC can separate GalNAc from other molecules based on their physical and chemical properties, while MS and NMR can identify the molecular structure of GalNAc and its derivatives.

BIOLOGICAL PROPERTIES:

GalNAc has many biological properties, including immune modulation, cell adhesion, and signal transduction. GalNAc-binding lectins, such as galectins and siglecs, play a crucial role in the immune system's function by recognizing and binding to specific carbohydrate structures. In addition, GalNAc-binding lectins are involved in various cellular processes, including cell adhesion, migration, and apoptosis.

TOXICITY AND SAFETY IN SCIENTIFIC EXPERIMENTS:

GalNAc is generally considered safe and non-toxic when used in scientific experiments. However, the toxicity of GalNAc and its derivatives may vary depending on the dose, route of administration, and duration of exposure. Studies have shown that GalNAc and its derivatives may have cytotoxic effects on cancer cells but not on normal cells.

APPLICATIONS IN SCIENTIFIC EXPERIMENTS:

GalNAc has various applications in scientific experiments, including the study of glycosylation, host-pathogen interactions, and signal transduction. GalNAc-binding proteins, such as galectins, have applications in immunology, cancer research, and drug development. In addition, GalNAc can be used as a substrate for the synthesis of glycoconjugates in chemical and enzymatic synthesis.

CURRENT STATE OF RESEARCH:

Research on GalNAc has increased significantly in recent years due to its relevance in many biological processes. Studies have shown that GalNAc and its derivatives play critical roles in the immune system's function, cell adhesion, migration, and signal transduction. GalNAc-binding lectins, such as galectins, have therapeutic potential in the treatment of various diseases, including cancer, inflammation, and autoimmune disorders.

POTENTIAL IMPLICATIONS IN VARIOUS FIELDS OF RESEARCH AND INDUSTRY:

GalNAc has potential implications in various fields of research and industry, including immunology, cancer research, drug development, and carbohydrate chemistry. GalNAc-binding proteins, such as galectins, have therapeutic potential in the treatment of various diseases, including cancer, inflammation, and autoimmune disorders. Furthermore, GalNAc is used as a substrate for the synthesis of glycoconjugates in chemical and enzymatic synthesis, which has applications in drug delivery, vaccines, and diagnostics.

LIMITATIONS:

GalNAc's limitations include its susceptibility to hydrolysis in acidic or alkaline environments and its cytotoxic effects on cancer cells. In addition, GalNAc-binding proteins, such as galectins, have limited specificity.

FUTURE DIRECTIONS:

Future directions for research on GalNAc include the synthesis of GalNAc derivatives with improved stability and specificity for GalNAc-binding proteins. Additionally, the development of new analytical methods for the identification and characterization of GalNAc and its derivatives is necessary. Moreover, research on the role of GalNAc and its derivatives in cellular processes and disease pathogenesis is required to fully understand their biological significance. The use of GalNAc in vaccine development and drug delivery systems also requires further investigation. Overall, further research on GalNAc is necessary to assess its potential implications in various fields of research and industry.

CAS Number14215-68-0
Product NameN-Acetyl-D-Galactosamine
IUPAC NameN-[(3R,4R,5R,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
Molecular FormulaC8H15NO6
Molecular Weight221.21 g/mol
InChIInChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1
InChI KeyOVRNDRQMDRJTHS-UHFFFAOYSA-N
SMILESCC(=O)NC1C(C(C(OC1O)CO)O)O
Solubility33.2 [ug/mL]
Canonical SMILESCC(=O)NC1C(C(C(OC1O)CO)O)O


CAS号: 1811-31-0,14215-68-0 别名: GalNAc2-Acetamino-2-deoxy-a-D-galactopyranoseN-Acetylchondrosamine MDL号: MFCD00065372 分子式: C8H15NO6 分子量: 221.21

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参考文献: 1. Matulic-Adamic J, Serebryany V, Haeberli P, et al., Bioconjugate Chem. 2002, 13, p1071


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